The No. 23 USC Trojans spoiled the part in Sin City on Sunday night, upsetting the No. 13 LSU Tigers 27-20 in front of a sellout crowd at Allegiant Stadium in Las Vegas.
Trojans' running back Woody Marks persevered into the end zone with eight seconds left to give USC the shocking victory over the heavily favorite LSU Tigers.
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The back-and-forth battle was an instant classic as both teams took turns tying the score and taking the lead at various points in the contest.
LSU kicker Daniel Ramos tied the game at 20-20 with 1:47 left, but USC, led by junior quarterback Miller Moss, marched down the field and punched the Tigers in the mouth with the game-winning score.
New LSU quarterback Garrett Nussmeier was intercepted by Mason Cobb on the first play of the ensuing drive, sealing the victory for USC.
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It was the debut of USC's new defense, now run by defensive coordinator D'Anton Lynn. Last year, USC's defense allowed nearly 35 points per game to their opponents, but in their opener against a top-ranked team, they held the Tigers to just 20 points.
It also marked the opening of the Miller Moss era for USC. Moss, a three-year backup quarterback behind Heisman Trophy winner Caleb Williams, threw for a bowl game record six touchdowns last December against Louisville in the Holiday Bowl.
Moss threw for 378 yards and a touchdown in the victory.
LSU had a new man behind center as well. Junior Garrett Nussmeier made his Tigers' debut as the full-time starting quarterback after backing up 2023 Heisman Trophy winner Jayden Daniels last season.
Nussmeier threw for 304 yards with two touchdowns and one interception in the loss.
Both offenses had no problems moving the ball throughout the game.
LSU marched down the field on their opening drive but were stopped by the Trojans' defense on a 4th and goal from the three-yard line.
USC opened the scoring on their second possession when senior running back Woody Marks ran up the middle for a two-yard touchdown run.
The drive was highlighted by a sensational one-handed grab by Kyron Hudson that will certainly be on SportsCenter later.
LSU answered on their ensuing drive. Nussmeier capped off a nine-play, 75-yard drive with a 19-yard touchdown pass to Kyren Lacy that evened the score.
The Tigers took their first lead of the game with 3:31 remaining in the third quarter. Nussmeier threw his second touchdown of the game on a wide receiver screen to sophomore Aaron Anderson that put LSU ahead 17-13.
Not to be outdone, the USC defense stopped the Tigers on consecutive drives, setting up Moss's first touchdown pass of the season, on a 28-yard dime to Ja'Kobi Lane to give the Trojans the lead at 20-17.
The victory marks the eighth consecutive win for USC in their season opener, but their 27 points are the fewest they've scored since they managed just six points in a blowout loss to Alabama at AT&T Stadium in 2016.
In his third year as head coach of USC, Lincoln Riley is a perfect 3-0 in season openers.
His counterpart, LSU head coach Brian Kelly, also in his third year at Baton Rouge, has lost all three of his season openers and it's the fifth consecutive loss for the Tigers in their season opener overall.
The sellout crowd of 65,000 was a 50-50 mixture of Tigers and Trojans fans. The game, affectionately called "The Beach vs. The Bayou," was loud and boisterous for both teams throughout the contest.
USC will return home to the LA Memorial Coliseum next Saturday where they will host Utah State in their home opener.