What to Know
- Tune into Patriots Pregame Live at 12 p.m. ET with Michael Holley, Tom E. Curran, Phil Perry and Albert Breer for a full game preview.
- Check out Patriots Postgame Live immediately following the game for instant analysis, player reactions and more.
- The Patriots enter as 10.5-point underdogs, but the 49ers could be without several key players.
- Kickoff is set for 4:05 p.m. ET at Levi's Stadium.
If the New England Patriots want to avoid falling to 1-3 with their third straight loss, they'll need to upset the defending NFC champion San Francisco 49ers on the road. San Francisco has lost two straight, however, and is dealing with its own injury concerns.
Follow along below for live updates of Patriots-49ers.